Gyneocology
ashraf saber mashhad taraqi; Najmeh Tehranian; Somayeh Yousefi; Anoshrvan Kazemnejad
Volume 26, Issue 3 , September and October 2019, , Pages 337-343
Abstract
Background and Aims: one of the hormones that appears to play an important role in regulating body growth is ghrelin. This study aimed to determine the association between Maternal serum ghrelin level and neonatal anthropometric indicators at birth.Materials & Methods: In this cohort study, 35 eligible ...
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Background and Aims: one of the hormones that appears to play an important role in regulating body growth is ghrelin. This study aimed to determine the association between Maternal serum ghrelin level and neonatal anthropometric indicators at birth.Materials & Methods: In this cohort study, 35 eligible pregnant women in their first trimester that were allocated by Using Convenience sampling were divided and matched in terms of BMI before pregnancy into normal and higher than normal BMI groups A ( n=14) and B ( n=21). Serum ghrelin level was measured during 6-12 and 15-20 weeks of gestation using ELISA method.Results: Mean non-fasting serum gherlin level (first and second trimesters) had not significant deference between two groups (p1=0.93, p2=0.76, in first and second trimester, respectively). Also there is a ascending increase in mean serum ghrelin level with increasing gestational age from the first to the second trimesters in both groups but was not significant (pa=0.15, pb=0.24, in A and B group, respectively). No significant correlations were detected between non-fasting serum gherlin level (first and second trimesters) and neonatal anthropometric indicators.Conclusion: The lack of any direct relationship between Maternal serum ghrelin level and neonatal anthropometric indicators does not support the hypothesis that ghrelin has major role in foetal growth
Pediatric
Ashraf Saber; Najmeh Tehranain; Shiva Pourali Roudbaneh; Matin Sadat Esmailzade
Volume 25, Issue 6 , November and December 2018, , Pages 829-844
Abstract
Background: Adipose tissue communicates with other central organs and the environment through the synthesis and release of substances called adipokines. Visfatin is an adipocytokine and a polyotropic protein whose function acts not only as an enzyme, but as an adipocytokine, a growth factor, and cytokine ...
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Background: Adipose tissue communicates with other central organs and the environment through the synthesis and release of substances called adipokines. Visfatin is an adipocytokine and a polyotropic protein whose function acts not only as an enzyme, but as an adipocytokine, a growth factor, and cytokine as well. Over the past few years, new roles have emerged for visfatin in terms of fertility and reproduction. The purpose of the present study is to summarize the current knowledge on this subject.Methods: In the present study, 137 full-text and short articles were obtained and reviewed through the electronic search by entering the relevant key words in Sciencedirect, Pubmed, Google scholar, Google published from 1993 to 2016.Results: The results of several studies support the strong association of visfatin with insulin resistance-related diseases such as type 2 diabetes, gestational diabetes, preeclampsia, and PCOD. In addition, with the deviation of embryo development from its natural course (embryo growth limitation and macrosomia), the initiation of labor is associated with sexual maturation (spermatogenesis) in males and the increase in the number and quality of oocytes in people with PCOD undergoing Infertility treatment through stimulating inflammatory responses.Conclusion: The results of this review report confirm the role of visfatin in fertility and reproduction. Further research to understand the relationship between visfatin and fertility disorders and pregnancy complications is needed in order to find possible medical treatments.